@tiefpunkt Yes, I believe you would need to make RPM packages of the dependencies, if they are not already available in repositories.
It has been a while since I built RPMs. If I have to do it now, my first preference would be to use solutions like AppImage, Snap or Flatpak, as they were created to solve this exact problem.
As your application is Python based, another possibility would be to use Conda. Most of the dependencies might already be available in Anaconda repositories.
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