strohfelder<p>I felt the need to thoroughly read — and comment on — the rightly hyped recent publication in Nature Medicine:</p><p>Tessier, AJ., Wang, F., Korat, A.A. et al.<br>Optimal dietary patterns for healthy ageing<br><a href="https://doi.org/10.1038/s41591-025-03570-5" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1038/s41591-025-035</span><span class="invisible">70-5</span></a></p><p>It’s a remarkable study with some unexpected results — especially the relative importance of monounsaturated fatty acids (MUFAs) via the MUFA:SFA ratio, and yes, the positive performance of wine. But let’s not get into that here 😉</p><p>This study certainly doesn’t offer the holy grail for healthy ageing, nor a clear guide on what (or how much) to eat.<br>Any attempt to treat it that way is, in my view, misleading.</p><p>What it does show are dietary patterns that correlate with better ageing outcomes — not prescriptive rules.</p><p>In fact, many of the foods with log(OR) ≥ 0 are low in calories and would not sustain daily energy needs on their own. That’s precisely the point.</p><p>Certain foods — even in small quantities — can have disproportionate biological impact.<br>This supports the view that dietary quality is more relevant than quantity in promoting healthy ageing.</p><p>And importantly, the fact that many of these protective foods are not modern dietary staples opens the door for nutritional interventions — including targeted supplementation — to deliver the benefits of these patterns in a more accessible form.</p><p><a href="https://fediscience.org/tags/longevity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>longevity</span></a> <a href="https://fediscience.org/tags/healthyaging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>healthyaging</span></a> <a href="https://fediscience.org/tags/nutrition" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>nutrition</span></a> <a href="https://fediscience.org/tags/science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>science</span></a></p>