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#FOAMed

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St Emlyn's

Explore the variability in maintaining PHEA for trauma patients. With insights into drug protocols, administration methods, and governance. #FOAMed @stemlyns

stemlynsblog.org/maintenance-o

St.Emlyn's · Maintenance of Prehospital Anaesthesia in Trauma Patients: Variability in PracticeExplore the variability in maintaining prehospital anaesthesia for trauma patients in this comprehensive summary of a multinational survey. With insights into drug protocols, administration methods, and governance, the article highlights challenges and opportunities for standardisation in prehospital care. Ideal for clinicians and researchers aiming to optimise anaesthesia practices and enhance patient outcomes in emergency settings. #FOAMed @stemlyns
Public
St Emlyn's

Let's catch up on some great conferences from 2025. In this blog David Purkarthofer from Austria reviews the highlights from the fantastic EuSEM conference held in Copenhagen earlier this year, and looks forward to Vienna in 2025. #FOAMed @stemlyns

stemlynsblog.org/eusem-2024-in

St.Emlyn's · EuSEM 2024 in reviewDavid Purkarthofer reviews the highlights from the fantastic EuSEM conference held in Copenhagen earlier this year. #FOAMed @stemlyns
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Christos Argyropoulos MD, PhD

"Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19"

Paper #FOAMed link:
cell.com/cell-host-microbe/ful

Nice video:
cell.com/cms/10.1016/j.chom.20

My comment:

Cognitive Behavioral Therapy, exercise therapy, pacing, Vitamin D, sunlight, and anti-depressants are guaranteed to help with that 😎👊

Public *
Christos Argyropoulos MD PhD

"Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19"

Paper #FOAMed link:
cell.com/cell-host-microbe/ful

Nice video:
cell.com/cms/10.1016/j.chom.20

My comment:

Cognitive Behavioral Therapy, exercise therapy, pacing, Vitamin D, sunlight, and anti-depressants are guaranteed to help with that 😎👊

Graphical abstract for the text abstract: SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using optical clearing and imaging, we observed the accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients, persisting long after viral clearance. Further, biomarkers of neurodegeneration were elevated in the cerebrospinal fluid from long COVID patients, and proteomic analysis of human skull, meninges, and brain samples revealed dysregulated inflammatory pathways and neurodegeneration-associated changes. Similar distribution patterns of the spike protein were observed in SARS-CoV-2-infected mice. Injection of spike protein alone was sufficient to induce neuroinflammation, proteome changes in the skull-meninges-brain axis, anxiety-like behavior, and exacerbated outcomes in mouse models of stroke and traumatic brain injury. Vaccination reduced but did not eliminate spike protein accumulation after infection in mice. Our findings suggest persistent spike protein at the brain borders may contribute to lasting neurological sequelae of COVID-19.
Public
St Emlyn's

New critical review of Systematic Review paper on large vs small chest drains in haemothorax. How low can you go?? Probably smaller than you think for many stable patients #FOAMed @stemlyns

stemlynsblog.org/jc-small-vers

St.Emlyn's · JC: Small versus Large-Bore Thoracostomy for Traumatic Hemothorax.Traditionally, large-bore chest tubes have been standard for managing haemothorax, but smaller tubes are now proving just as effective in stable patients, with added benefits like reduced pain and fewer tube days. This review explores outcomes in drainage efficacy, complication rates, and patient comfort, showing that small-bore thoracostomy may be a reliable alternative for non-emergent cases. However, for severe trauma or urgent settings, large-bore remains the go-to option. This evidence-based article helps trauma professionals make informed decisions about thoracostomy tube size, keeping patient outcomes and comfort at the forefront. Dive in to explore the latest evidence in trauma management and see if small-bore thoracostomy is suitable for your practice’s patient population.
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